Imperial’s interdisciplinary expertise in biotechnology leads the UK field and spans many disciplines. Many of our experts work together as part of the Industrial Biotechnology Hub and Agri-Net which are dedicated to developing innovative solutions for industry and government agencies.
Areas of expertise include...
Microbial Strain Engineering, Design and Improvement.
With increased environmental and economic constraints on industries, the bioproduction of molecules is becoming a sustainable alternative to traditional methods. To scale it up to industrial production, we still need significant improvements in the methods, using genetic engineering and metabolic engineering.
Engineered micro-organisms have a wide range of applications in
- Oil and Gas - e.g. production of biodiesel, biokerosene, hydrogen, and electricity from renewable sources
- Pharmaceuticals - e.g. production of active compounds, biosensors, microbiome engineering
- Chemicals - e.g. production of bulk chemicals or high value compounds
- Engineering - e.g. production of novel materials and biological circuits
Dr Rodrigo Ledesma-Amaro's group at Imperial have a vast knowledge of microbial metabolism, and its regulation, in organisms ranging from yeast and fungi to bacteria. Through engineering-based improvements - such as increasing resistance to inhibitors, enabling the use of low-cost substrates and maximising the production of a desired compound - they can 'tailor' micro-organisms to perform desired tasks in a cost-efficient manner - and guide you on the downstream process.
The group's expertise includes:
- Development of synthetic biology, metabolic engineering and molecular biology tools.
- Rational metabolic engineering for bioproduction.
- Metabolic modelling as a tool to identify engineering targets.
- Decreasing bioproduction cost by strain improvement at different levels.
- Reliable chassis strains generation.
- Selecting the best host for each product and process.
- High-throughput strain improvement techniques.
- Dr Rodrigo Ledesma-Amaro - leads a research group at the interface of synthetic biology and metabolic engineering. His expertise includes microbial biotechnology and communities, applications in industrial biotechnology and biomedicine.
Further expertise areas at Imperial include: