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Published Animal Models

 

Papers from interactions with biotech companies

  1. A.B. Vogel, L. Lambert, E. Kinnear, D. Busse, S. Erbar, K.C. Reuter, L. Wicke, M. Perkovic, T. Beissert, H. Haas, S.T. Reece, U. Sahin, J.S. Tregoning*. Self-amplifying RNA vaccines give equivalent protection against influenza to mRNA vaccines but at much lower doses. Molecular Therapy. 2018. Partner Biontech
  2. Gould VMW, Francis JN, Anderson KJ, Geroges B, Cope AV, Tregoning JS+. 2017. Nasal IgA Provides Protection against Human Influenza Challenge in Volunteers with Low Serum Influenza Antibody Titre. Frontiers in Microbiology. 8: 900. Partner Altimmune
  3. Laura Lambert, Ekaterina Kinnear, Jacqueline U. McDonald, Gunnveig Grodeland, Bjarne Bogen, Elisabeth Stubsrud, Mona M. Lindeberg, Agnete Brunsvik Fredriksen, John S. Tregoning+. 2016. DNA Vaccines Encoding Antigen Targeted To MHC Class II Induce Influenza Specific CD8+ T Cell Responses, Enabling Faster Resolution Of Influenza Disease. Frontiers in immunology. 7: 321. Partner Vaccibody
  4. E. Kinnear, L.J. Caproni, J. S. Tregoning+. 2015. A Comparison of Red Fluorescent Proteins to Model DNA Vaccine Expression by Whole Animal In Vivo Imaging. PLoS One. 10: e0130375. Partner Touchlight Genetics
  5. A.A. Walters, E. Kinnear, R.J. Shattock, J.U. McDonald, L.J. Caproni, N. Porter and J.S. Tregoning+. 2014. Comparative analysis of enzymatically produced novel linear DNA constructs with plasmids for use as DNA vaccines. Gene Therapy. 21:645-52. Partner Touchlight Genetics

 

Influenza

  1. H.T. Groves, J. McDonald, P. Langat, E. Kinnear, P. Kellam, C. Thompson, J. Ellis, J. McCauley, R. Elderfield, L. Parker, W. Barclay, J.S. Tregoning+. Mouse models of influenza infection with circulating strains to test seasonal vaccine efficacy. Frontiers in Immunology. 9: 126.
  2. A.B. Vogel, L. Lambert, E. Kinnear, D. Busse, S. Erbar, K.C. Reuter, L. Wicke, M. Perkovic, T. Beissert, H. Haas, S.T. Reece, U. Sahin, J.S. Tregoning*. Self-amplifying RNA vaccines give equivalent protection against influenza to mRNA vaccines but at much lower doses. Molecular Therapy.
  3. de Silva TI, Gould V, Mohammed NI, Cope A, Meijer A, Zutt I, Reimerink J, Kampmann B, Hoschler K, Zambon M, Tregoning JS. 2017. Comparison of mucosal lining fluid sampling methods and influenza-specific IgA detection assays for use in human studies of influenza immunity. Journal of Immunological Methods. 449:1-6
  4. Gould VMW, Francis JN, Anderson KJ, Geroges B, Cope AV, Tregoning JS+. 2017. Nasal IgA Provides Protection against Human Influenza Challenge in Volunteers with Low Serum Influenza Antibody Titre. Frontiers in Microbiology. 8: 900.
  5. McDonald JU, Zhong Z, Groves HT, Tregoning JS+. 2017. Inflammatory Responses to Influenza Vaccination at the Extremes of Age. Immunology. 151:451-63
  6. Laura Lambert, Ekaterina Kinnear, Jacqueline U. McDonald, Gunnveig Grodeland, Bjarne Bogen, Elisabeth Stubsrud, Mona M. Lindeberg, Agnete Brunsvik Fredriksen, J.S. Tregoning+. 2016. DNA Vaccines Encoding Antigen Targeted To MHC Class II Induce Influenza Specific CD8+ T Cell Responses, Enabling Faster Resolution Of Influenza Disease. Frontiers in immunology. 7: 321.
  7. J.F.S. Mann, J.S. Tregoning, Y. Aldon, R.J. Shattock and P.F. McKay. 2016. CD71 targeting boosts immunogenicity of sublingually delivered influenza haemagglutinin antigen and protects against viral challenge in mice. Journal of Controlled Release. 232: 75-82.
  8. R.F. Russell, J.U. McDonald, L. Lambert, J.S. Tregoning+. 2016. Use of the microparticle NanoSiO2 as an adjuvant to boost vaccine immune responses in neonatal mice against influenza. J. Virol. 90: 4735-44

 

RSV

  1. Ekaterina Kinnear, Laura Lambert, Jacqueline U. McDonald, Hannah M. Cheeseman, Lisa J. Caproni, John S. Tregoning+. 2017. Airway T cells protect against RSV infection in the absence of antibody. Mucosal Immunology. 11: 290
  2. IFN-γ from NK & T cells inhibit neonatal antibody. John S. Tregoning, Belinda Lei Wang, Jacqueline U. McDonald, YukoYamaguchi, James A. Harker, Michelle Goritzka, Cecilia Johansson, Alexander Bukreyev, Peter L. Collins, Peter J. Openshaw. Proceedings of the National Academy of Sciences Apr 2013, 110 (14) 5576-5581; DOI:10.1073/pnas.1214247110
  3. Harker JA, Yamaguchi Y, Culley FJ, Tregoning JS, Openshaw PJ. Delayed sequelae of neonatal respiratory syncytial virus infection are dependent on cells of the innate immune system. J Virol. 2014 Jan;88(1):604-11. doi: 10.1128/JVI.02620-13.

 

 

Non-typeable Haemophilus influenzae (NTHI)

  1. Siggins MK, Gill SK, Langford PR, Li Y, Ladhani SN, Tregoning JS. PHiD-CV induces anti-Protein D antibodies but does not augment pulmonary clearance of non typeable Haemophilus influenzae in mice. Vaccine. 2015 Sep 11;33(38):4954-61. doi: 10.1016/j.vaccine.2015.07.034.

 

Pseudomonas aeruginosa

  1. Mallia P, Webber J, Gill SK, Trujillo-Torralbo MB, Calderazzo MA, Finney L,Bakhsoliani E, Farne H, Singanayagam A, Footitt J, Hewitt R, Kebadze T, AniscenkoJ, Padmanaban V, Molyneaux PL, Adcock IM, Barnes PJ, Ito K, Elkin SL, Kon OM,Cookson WO, Moffat MF, Johnston SL, Tregoning JS. Role of airway glucose inbacterial infections in patients with chronic obstructive pulmonary disease. JAllergy Clin Immunol. 2017 Dec 13. pii: S0091-6749(17)31743-8. doi: 10.1016/j.jaci.2017.10.017.
  2. Gill, Simren K., Kailyn Hui, Hugo A. Farne, James Peter Garnett, Deborah L. Baines, Luke S. P. Moore, Alison H. Holmes, Alain Filloux and John S Tregoning. “Increased airway glucose increases airway bacterial load in hyperglycaemia.” Scientific reports (2016).
  3. Åstrand A, Wingren C, Benjamin A, Tregoning JS, Garnett JP, Groves H, Gill S,Orogo-Wenn M, Lundqvist AJ, Walters D, Smith DM, Taylor JD, Baker EH, Baines DL. Dapagliflozin-lowered blood glucose reduces respiratory Pseudomonas aeruginosa infection in diabetic mice. Br J Pharmacol. 2017 May;174(9):836-847. doi: 10.1111/bph.13741.

  

Pre-clinical vaccine development

  1. E. Kinnear, L.J. Caproni, J. S. Tregoning+. 2015. A Comparison of Red Fluorescent Proteins to Model DNA Vaccine Expression by Whole Animal In Vivo Imaging. PLoS One. 10: e0130375.
  2. A.A. Walters, E. Kinnear, R.J. Shattock, J.U. McDonald, L.J. Caproni, N. Porter and J.S. Tregoning+. 2014. Comparative analysis of enzymatically produced novel linear DNA constructs with plasmids for use as DNA vaccines. Gene Therapy. 21:645-52.